Jonathan Scholey
نویسنده
چکیده
Jon Scholey is Professor of Cell Biology at the University of California, Davis, where he studies molecular motors, microtubule-based motility and protein machines. His current research focuses on intraflagellar transport and cilium biogenesis, the assembly and function of the mitotic spindle, and (with mathematician Alex Mogilner) the quantitative modeling of mitosis and motility. He teaches an undergraduate class in cell biophysics and a graduate class in cell biochemistry.
منابع مشابه
Mitotic Motors: Kinesin-5 Takes a Brake
A kinesin-5-dependent 'sliding filament' mechanism is commonly used to actively push apart the poles during mitotic spindle assembly and elongation, but a recent study now shows that, in C. elegans, kinesin-5 is deployed as a brake to slow down spindle-pole separation.
متن کاملModeling mitosis.
The mitotic spindle is a fascinating protein machine that uses bipolar arrays of dynamic microtubules and many mitotic motors to coordinate the accurate segregation of sister chromatids. Here we discuss recent mathematical models and computer simulations that, in concert with experimental studies, help explain the molecular mechanisms by which the spindle machinery performs its crucial function...
متن کاملCilium Assembly: Delivery of Tubulin by Kinesin-2-Powered Trains
The kinesin-2-driven anterograde transport of intraflagellar transport (IFT) trains has long been suspected to deliver cargo consisting of tubulin subunits for assembly at the axoneme tip. Important new work identifies the tubulin binding site on IFT trains that is responsible for this cargo transport.
متن کاملMitosis, microtubules, and the matrix
The mechanical events of mitosis depend on the action of microtubules and mitotic motors, but whether these spindle components act alone or in concert with a spindle matrix is an important question.
متن کاملIntraflagellar transport at a glance.
Intraflagellar transport (IFT) is the bidirectional transport of multisubunit protein complexes, called IFT particles, along axonemal microtubules (MTs) beneath the ciliary membrane. IFT plays essential roles in the assembly and function of cilia and flagella by contributing to cell motility, sensory perception and ciliumbased signaling (Rosenbaum and Witman, 2002; Scholey, 2003). IFT was first...
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عنوان ژورنال:
- Current Biology
دوره 16 شماره
صفحات -
تاریخ انتشار 2006